AVP-stimulated AQP2 expression depends on prorenin activation of PRR (Wang et al., 2016), conditional deletion of PRR in the CD, and the whole nephron causes a common polyuria phenotype with consistent inhibition of renal AQP2 and V2R expression and AVP sensitivity (Ramkumar et al., 2015; Trepiccione et al., 2016; Wang et al., 2016). This evidence concerns the gene AVP and Polyuria.