IGF1R and intrahepatic cholangiocarcinoma: It is consistent with our study that the IGF-1/IGF-1R signaling was distinctly reduced in the diabetic rats with lots of apoptotic ICC, while EA could improve the IGF-1/IGF-1R signaling and decrease the quantity of apoptotic ICC, indicating that EA partly activates the IGF-1/IGF-1R signaling to prevent the apoptosis of ICC.