In our study, we found that the expression of the Nrf2/HO-1 pathway was not increased in diabetic rats, and furthermore, EA significantly improved the expression of the Nrf2/HO-1 pathway, meaning that EA may take effects on the Nrf2/HO-1 pathway to reduce ICC apoptosis in diabetic gastroparesis rats. Here, NFE2L2 is linked to intrahepatic cholangiocarcinoma.