CD4 and infection: In fact, it was reported that, in COVID-19, white cells immunity acts as in a classical respiratory virus-like infection (Jansen et al., 2019; Azkur et al., 2020): recognition of the whole virus and viral particles by professional antigen-presenting cells, which are mainly dendritic cells and macrophages, that present viral peptides to CD4+ T cells; activation of CD8+ cytotoxic T cells to lyse the virus-infected cells; activation of B cells that can directly recognize the viruses and also interact with CD4+ T cells.