In this study, XPF rectified the injury of the hippocampus and myocardium caused by CHD in depressed rats, significantly decreasing the hippocampal and myocardial levels of Bax, Cyt-c, caspase-3, and increased Bcl-2 expression, which suggests that XPF may inhibit hippocampal and myocardial apoptosis, improve heart function and nerve function, and exert antidepressant and anti-myocardial ischemia effects. The gene discussed is BCL2; the disease is myocardial ischemia.