NR3C1 and Wilson disease: Studies on the effects of short- and long-term WD on hypothalamic and hippocampal inflammatory reactions in mice exposed to acute LPS-induced inflammation have shown that animals on a HFD diet have a significant increase in the expression of glucocorticoid receptor of the hypothalamus after LPS stimulation compared to WD mice in which this expression is markedly lower (De Souza et al., 2005; Milanski et al., 2009; Thaler et al., 2012; Pohl et al., 2014; Astiz et al., 2017).