Tau tracer binding in AD is not only increased in regions that are known to be affected in early Braak stages (Cho et al., 2016; Schöll et al., 2016; Kitamura et al., 2018; Gordon et al., 2019; Harrison et al., 2019), but also globally heightened in the cortex (Cho et al., 2016; Pontecorvo et al., 2019). This evidence concerns the gene MAPT and Alzheimer disease.