A case-control study in patients with rheumatoid arthritis (who have a slightly higher risk for AD) showed a significant reduction of AD incidence by 70% (adjusted Odds ratio of 0.30, p = 0.02) if the patients were treated with the tumor necrosis factor α inhibitor etanercept (Chou et al., 2016), as long as it was well tolerable (Butchart et al., 2015). This evidence concerns the gene TNF and Alzheimer disease.