Interestingly, though, in human RPE-derived ARPE-19 cells, recent evidence suggests that this cytokine induces expression of BRAF-activated non-coding RNA (BANCR), a regulatory transcript involved in immunopathological processes (Kutty et al., 2018); inhibition of IFN-γ has therefore been postulated as a potential therapeutic option in AMD. Here, IFNG is linked to age-related macular degeneration.