In fact, this may be due to the increase in p-NKCC1, which regulates the entry of substances such as Na+, K+, CI–, and water into cells, change cell volume, and destroy the cytoskeletal structure of cells, leading to cell swelling, increased BBB permeability, and albumin leakage, ultimately resulting in brain edema. The gene discussed is SLC12A2; the disease is brain edema.