PLOD1 and Anxiety: HCRT is closely associated with wakefulness and narcolepsy (Soya and Sakurai, 2020) because of its role in the regulation of vigilance and arousal states (Boutrel and de Lecea, 2008), so it raises the question of if the BST-HCRT-LH pathway can help explain the sleep disruptions commonly associated with anxiety (American Psychiatric Association, 2013).