Infusion of the BST with urocortin-1 (Ucn-1), a CRHR1 and CRHR2 agonist (Vaughan et al., 1995), was shown by Donner et al. (2020) to increase DRD tph2 mRNA, suggesting that DRD serotonergic neurons are regulated by BST-CRH neurons and help promote anxiety-like states. The gene discussed is CRH; the disease is Anxiety.