Circ-RUNX2 88, circ-VANGL1 89, circ-0011269 90, circ-0076906 91, circRNA-0016624 92, circ-0006393 93, circRNA-0048211 94, circ-SLC8A1 95, circ-YAP1 96 and circ-0076690 97 are found down-regulated in osteoporosis and could enhance osteogenesis of BMSCs by sponging miRNAs and subsequently upregulating the expression and activities of osteogenetic genes (such as RUNX2, BMP2, OPN, OCN, OGN, FOXO1, APAK2 or ALP) (Figure 4A). Here, RUNX2 is linked to osteoporosis.