Especially in recent years, there have been experiments to prove that LRRC4 is involved in nasopharyngeal carcinoma, pituitary adenoma and epithelial ovarian cancer 15, 40, 41, and more importantly, a certain common germline variant in LRRC4C has been implicated in confer increased risk of developing tumors in the central nervous system during childhood 42. The gene discussed is LRRC4; the disease is ovarian carcinoma.