Recently, Phung et al. developed an anti-cancer strategy based on DC-derived exosomes: anti-CTLA-4 antibody was anchored in lipids of exosomes of DCs, which guide the exosomes towards T cells, in addition, they endowed the exosomes with ability to block checkpoint, both enhancing the T cell response to cancer cells synergistically 75. The gene discussed is CTLA4; the disease is cancer.