The STIM1 mediated SOCE activation also involved in this process, and the knockdown of STIM1 or pharmacological inhibition of SOCE can reversed anti-cancer effect of DIM by inhibiting p-AMPK-mediated ER stress, indicating that STIM1 mediated SOCE might be a critical step for DIM induced cells death (Figure 8). Here, STIM1 is linked to cancer.