Here, these results confirm that PI3K/AKT pathway accelerated proliferation of lung cancer cells and MAPK/ERK pathway facilitated proliferation of lung CSCs, consistent with the different expressions of the PI3K/AKT and MAPK/ERK signaling pathway-related genes between the lung cancer cells and lung CSCs (Figure 4A and 4B). This evidence concerns the gene PIK3CA and lung carcinoma.