In ischemic stroke mice, α7nAChR agonist reduced the brain injury through decreasing the phosphorylation of p65-NF-κB protein in microglia 25-27, demonstrating that α7nAChR-mediated inhibition of NF-κB signaling is a crucial neuroprotective mechanism against ischemic brain injury. Here, NFKB1 is linked to ischemic stroke.