MAPK3 and nonpapillary renal cell carcinoma: Ming Tang and his colleagues illustrated that FGL2 expression in fresh clear cell renal cell carcinoma (ccRCC) tissues was conspicuously up-regulated, furthermore, they confirmed that high expression level of FGL2 blockades ccRCC cell viability, activates ERK1/2 and p38 MAPK pathways, and promotes apoptosis (Figure 4) 75.