Compared with the NC group (α), ldrEXOs with high levels of circ-METRN (δ, ε) promoted proliferation, radioresistance, apoptosis resistance, invasion, and migration abilities of glioblastoma cell lines while ldrEXOs with inhibition of circ-METRN (ldrEXOs_siCIRC) (β, ζ) did not significantly exhibit the promoting effect (Figure 2A-E). This evidence concerns the gene METRN and glioblastoma.