In summary, the present study is the first to examine the circ-METRN levels in low-dose radiation-induced exosomes and to reveal the role of exosomal circ-METRN via miR-4709-3p/GRB14/PDGFRα pathway in understanding the pathogenesis of glioblastoma, providing novel insights for identifying new biomarkers or potential theranostic targets. This evidence concerns the gene METRN and glioblastoma.