F2RL1 and metastatic malignant neoplasm: In searching for the molecular mechanism downstream of PRSS1 that affects GC MGC803 cell proliferation, we found that PAR-2 was highly expressed in well-differentiated, moderately differentiated and poorly differentiated gastric adenocarcinoma and lymph node metastatic cancer tissues compared with normal gastric mucosa (Figure 6A, Table 4) as measured by IHC.