In searching for the molecular mechanism downstream of PRSS1 that affects GC MGC803 cell proliferation, we found that PAR-2 was highly expressed in well-differentiated, moderately differentiated and poorly differentiated gastric adenocarcinoma and lymph node metastatic cancer tissues compared with normal gastric mucosa (Figure 6A, Table 4) as measured by IHC. Here, PRSS1 is linked to metastatic malignant neoplasm.