Our pilot experiments also measured a series of inflammatory factors by ELISA Kits, including TNF-α, TGF-β, IFN-γ, IL-10, IL-6, IL-4, IL-1b, IL-2, IL-18, MMP2, MMP3, MMP8, and granzyme-B in the conditioned cell culture medium, mice serum and breast cancer cell xenograft in vivo and found that the cytokine levels of TNF-α and TGF-β were increased but IL-10 was reduced in the irradiated organisms, but the other cytokines had no significantly difference between group control and group RT. Here, IL18 is linked to breast cancer.