To identify genes with CNVs that were significantly associated with immune cell infiltrate, we evaluated the relationship between the most commonly CNV-affected genes of HCC (VEGFA, FGF3/4/19, CCND1, AXIN1, CDKN2A, CDKN2B, IRF2, MAP2K3, PTEN and RB1) and ESTIMATE immune infiltrate scores. Here, MAP2K3 is linked to hepatocellular carcinoma.