In consistent with previous findings49, some of the identified genes showing pleiotropic association with MDD were also associated with schizophrenia, such as BTN3A2, BTN3A3, PRSS16, HLA-C, C4A, and HLA-DMA, indicating a potential overlapped mechanism between schizophrenia and MDD. The gene discussed is HLA-C; the disease is major depressive disorder.