Specifically, we identified BTN3A2 (ENSG00000186470) that showed the most significantly pleiotropic association with MDD (β [SE] = 0.027 [0.004], P = 3.44 × 10−12; Supplementary Table S, 3), followed by RPL31P12 (ENSG00000227207, β [SE] = −0.039 [0.006], P = 3.43 × 10−11). The gene discussed is BTN3A2; the disease is major depressive disorder.