Further validation via another database revealed that 4 hub genes, ACAT1, SLC2A2, PCK1 and ABAT, were correlated with tumor survival of HCC in T2DM with HbA1c ≥ 6.5%, suggesting the prognostic prediction function of these 4 genes and even new therapeutic targets in HCC. Here, PCK1 is linked to type 2 diabetes mellitus.