Through the analysis, it was found that genes were enriched in cell communications and ECM organization in several significant modules of two diseases; additionally, the staining results showed the increasing deposition of collagen type IV and α-smooth muscle actin (α-SMA) in liver of T2DM patients, indicating that hepatic ECM remodeling with overnutrition played a crucial role in liver malignancy [22]. The gene discussed is ACTA1; the disease is overnutrition.