Both Kir4.1 and AQP4 are anchored by Dystrophin 71 (Dp71) on the membranes of Müller cells.16, 17 It was reported that the swelling of Müller cells was caused by the downregulation or redistribution of Kir4.1, AQP4 and Dp71 in many disease models, such as retinal vein occlusion and ischemia-reperfusion injury.18, 19. Here, AQP4 is linked to ischemia reperfusion injury.