NR4A1 and breast cancer: When mediation analysis was stratified by hormone receptor status, it appeared that the association between MHT and BC risk was limited to hormone receptor-positive breast cancers: the total effect of MHT was 1.58 (0.93 to 2.64), resulting from a direct effect of 1.44 (0.85 to 2.34) and indirect effects of 1.22 (1.06 to 1.52) through PMD and 0.91 (0.78 to 0.99) through BMI.