TP63 and split hand-foot malformation: TP63 mutations in human also cause severe developmental diseases, such as ectrodactyly ectodermal dysplasia–clefting syndrome (EEC), limb–mammary syndrome (LMS), ankyloblepharon and ectodermal dysplasia–clefting syndrome (AEC), split-hand/foot malformations (SHFM) and Rapp–Hodgkin syndrome [8].