And the overall survival analysis based on 530 kidney renal clear cell carcinoma samples revealed that FGF1 statistical significantly correlates with patients overall survival (OS), but not recurrence free survival (RFS), higher FGF1 gene expression directly associated with better patients overall survival indicating its potential tumor inhibitor function in ccRCC (Fig. 5a, b). This evidence concerns the gene FGF1 and nonpapillary renal cell carcinoma.