Considering our previous gene module analysis based on PPI network which showed that FGF1 involved PI3K-AKT signaling shall play a core role in the network, it’s of potential clinical value to further investigate the potential drug-targeting role of FGF1 gene or other FGF1 interacted PI3K-AKT signaling proteins in the development of ccRCC, thus aiding more precise understanding of the disease. This evidence concerns the gene FGF1 and nonpapillary renal cell carcinoma.