In the study, we combine used four different GEO cDNA expression profiles together with multiple bioinformatic analysis methods to explore the potential new prognostic indicators in ccRCC development, and we identified a specific FGF1 gene which was proved to be aberrant lost expression in ccRCC comparing to normal renal tissues, and the FGF1 lose of expression was indicated to be a worse overall survival indicator in ccRCC patients. The gene discussed is FGF1; the disease is nonpapillary renal cell carcinoma.