SFTPA1 and idiopathic interstitial pneumonia: The mechanisms behind the development of lung cancer in IPF have not yet been fully explored, but recent evidence seems to suggest that a common genetic predisposition may exist; mutations in the surfactant protein A1 (SFTPA1) gene were found in patients with IPF and lung adenocarcinoma, and an increased risk of developing interstitial lung diseases or other forms of cancer was found in the members of their families [152].