In conclusion, DCE-MRI quantitative perfusion histogram can be used as a noninvasive, in vivo and reproducible method to indirectly evaluate the activation of PI3K/Akt/mTOR signal pathway gene in lung cancer, and provide a way for MRI to evaluate tumor heterogeneity at the molecular level, which is of great significance to clinical practice. The gene discussed is MTOR; the disease is lung carcinoma.