CD8 T cells have active roles in controlling infections caused by other flaviviruses including West Nile virus (Grifoni et al., 2018; Klein et al., 2005; Shrestha and Diamond, 2004; Shrestha et al., 2006; Wang et al., 2003, 2006), DENV (de Alwis et al., 2016; Lam et al., 2017; Regla-Nava et al., 2018; Rivino and Lim, 2017; Shi et al., 2015; Yauch et al., 2009), and yellow fever virus (Akondy et al., 2009; Bassi et al., 2015; Co et al., 2009; Nogueira et al., 2013), which, given their relatedness, implies that CD8 T cells may be similarly important in limiting ZIKV infection. This evidence concerns the gene CD8A and infection.