CD8A and renal cell adenocarcinoma: In contrast, an elevated density and proliferation rate of CD8+Ki67+ T cells was significantly associated with high tumor stage, positive nodal stage, advanced ISUP, Fuhrman, Thoenes grading (each p ≤ 0.0225, Table 1) as well as shorter overall survival (p ≤ 0.0093 each, Fig. 2) in renal cell cancer.