In contrast, a high CD8+ cell density was linked to advanced ISUP/ Fuhrman/ Thoenes grading (each p < 0.0001, Table 1) and poor outcome (overall survival p = 0.033, Fig. 2; progression free survival p = 0.00047, Supplementary Fig. 2) in renal cell cancer. Here, CD8A is linked to renal cell adenocarcinoma.