MKI67 and colorectal cancer: In colorectal cancer, the multivariate analysis revealed that tumor stage (p < 0.0001), nodal stage (p < 0.0001) as well as the density of CD8+ (p = 0.0132) and the CD8+Ki67+ T lymphocyte density (p = 0.0098) were independent risk factors, while the percentage of proliferating CD8+ cells was not an independent predictor (p = 0.23).