It was shown, that wild type 223Gln>Gln LEPR is statistically more common in women with HER2 negative breast cancer (W vs. V p = 0.019) and wild type form of 2548G>A LEP is more common in women with PR positive breast cancer (WW vs. WV, VV p = 0.022). The gene discussed is PGR; the disease is breast carcinoma.