In this context, it is emphasized the importance of evaluation of CYP24A1 gene as a crucial advanced diagnostic tool in the definitive diagnosis of IIH; furthermore, the CYP24A1 PVs identification can be useful for the improvement of target therapeutic strategies, principally aimed to the control of calcium imbalance and the prevention of progression to chronic kidney disease. This evidence concerns the gene CYP24A1 and pseudotumor cerebri.