To further probe the specific identity of tumor-infiltrating lymphocytes (TILs), we performed a subset analysis using well-characterized immune-based markers to differentiate between CD3 + CD8 + (CD8), T-helpers CD3 + CD4 + CD25-FOXP3- (CD4 conv), CD3 + CD4 + CD25 + FOXP3 + (CD4 Tregs), CD56 + NK cells, myeloid and granulocytic populations (Supplementary Table 4). Here, CD4 is linked to neoplasm.