SHBG and endocrine system disorder: Similar associations in relation to sex hormones and SHBG were observed after excluding the first two years of follow-up (Supplementary Fig. S3), and after excluding pre- and post-menopausal women with self-reported endocrine disorders, pre-menopausal women with irregular menstrual cycles, pre- and post-menopausal women with a concentration of testosterone which was below the reportable range, and pre-menopausal women with a concentration of oestradiol below the reportable range (Supplementary Table S2).