CDH1 and colorectal carcinoma: Treatment of CRC cells with a Wnt inhibitor (IWR-1-endo) or an activator (SKL2001) for 24 h indicated that suppression or activation, respectively, of Wnt signaling had a low magnitude effect on MEF2A expression but greatly increased or repressed, respectively, the expression of E-cadherin (Fig. 6h).