For TGYP, the main components are Chaihu, Diding, Huangqi and Danggui and it is noteworthy that other studies have reported that Huangqi could relieve HBV induced hepatitis by inhibiting NF-κB signaling15, and Chaihu could promote HBeAg clearance by inhibiting HBV replication16,17. Here, NFKB1 is linked to Hepatitis.