In the comparison of patients with RA with functional disability versus patients with RA without functional impairment, there were no differences observed in other adipokines (adiponectin, leptin, resistin and visfatin), cytokines (IL-6, TNF-α, IL-1β and IL-18), E-selectin, rheumatoid factor, or ESR. This evidence concerns the gene IL18 and rheumatoid arthritis.