TERT and cancer: We next sought to define whether the six MBCs harboring TERT gene promoter hotspot mutations or gene amplification displayed a distinct repertoire of somatic genetic alterations as compared to the 38 TERT wild-type MBCs (Fig. 3, Supplementary Table S2) subjected to whole-exome sequencing (WES) or MSK-IMPACT targeted sequencing of 341–468 cancer-related genes.