It should be noted that pathogenic mutations affecting TP53 and TERT promoter hotspot mutations have also been found to be inversely correlated in other cancer types16,32, whereas TERT promoter and PIK3CA hotspot mutations have been shown to be mutually exclusive in ovarian cancers33, but to co-occur in other cancer types34,35, including breast cancer19. The gene discussed is PIK3CA; the disease is cancer.