JAG1 and colorectal carcinoma: To test if DUSP16 regulates sensitivity to cisplatin in other cancer cells, its expression in CRC cell lines DLD-1 and HCT116 (Fig. 1E and Supplementary Fig. 1C), and the gastric cancer cell lines Ags and Nugc3 (Fig. 1F and Supplementary Fig. 1D) was examined.