MAPK8 and colorectal carcinoma: In this study, prolonged activation of JNK and p38 in NPC HK-1 and C666-1 cells, and CRC DLD-1 cells, gastric cancer Nugc3 cells, and breast MDA-MB-231 cells in response to chemotherapeutic agents was observed and DUSP16 expression inhibited both JNK and p38 activation in all the cell lines (Fig. 4A–C and Supplementary Figs. 2D, 3, 4, 6), which was associated with reduced apoptosis (Fig. 2 and Supplementary Figs. 2–5).