These results are in line with our observations in HK-1 cells, where overexpression of DUSP16 resulted in inhibited JNK and p38 activation, increased c-Myc expression, and reduced cell apoptosis (Figs. 3B and 4A), suggesting that DUSP16 negatively regulates cisplatin-mediated apoptosis in NPC cells by regulating the MAPK pathways, namely JNK and p38. This evidence concerns the gene DUSP16 and nasopharyngeal carcinoma.