MAPK8 and cancer: To explore if DUSP16 commonly regulates cancer cell sensitivity to chemotherapeutic agents through JNK and p38, we treated vector- or DUSP16-expressing HCT116, HK-1, Nugc3, and MDA-MB-231 cells with 5-Fluorouracil (5-FU) or epirubicin to examine cell apoptosis.