In summary, our study demonstrates that DUSP16 targets JNK and p38 to regulate the common cell death pathway, the BAX/caspase 3–caspase 9 pathway, in various types of solid tumors, including NPC, CRC, gastric cancer, and breast cancer to regulate chemotherapy-induced apoptosis. The gene discussed is MAPK8; the disease is nasopharyngeal carcinoma.