To further elucidate the function of DUSP16 in cancer response to chemotherapy, we overexpressed this molecule in the NPC cell line HK-1, the CRC cell line DLD-1, and HCT116, the gastric cancer cell line Nugc3 as well as the breast cancer cell line MDA-MB-231. This evidence concerns the gene DUSP16 and nasopharyngeal carcinoma.