Class 2a weights were associated with TP53 (p = 4.51 × 10−9; Wilcoxon rank-sum test) and TSC1 (p = 1.37 × 10−5; Wilcoxon rank-sum test) mutations, as well as to higher tumor stage, tumor grade and EORTC risk score. The gene discussed is TSC1; the disease is neoplasm.