We found that the expression levels of some genes enriched in IL-11+ fibroblasts, including Wnt5a, Mmp13, Timp1, Il1rl1, Cxcl5, Saa3, Inhiba, Ascl4, and Tnfrsf11b, were elevated in mouse AOM/DSS-induced colon tumor tissues (Supplementary Fig. 5b). This evidence concerns the gene ASCL4 and colonic neoplasm.