While in BALF, the authors identified several hyper-inflammatory cell subtypes, including Macro_c2-CCL3L1, Mono_c1-CD14-CCL3, Mono_c2-CD14-HLA-DPB1, and Mono_c3-CD14-VCAN clusters and neutrophils, suggesting those immune subsets as potential sources provoking localized inflammatory response in the lungs (Fig. 1b), which in part is consistent with Zhang et al. who reported the presence of CD14+ in severe COVID-19.2 This evidence concerns the gene CD14 and COVID-19.