PARP1 and Hypoglycemia: Higher methylation of leucine-rich alpha-2-glycoprotein 1 (a protein associated with neurodevelopment), as well as upregulation of poly (ADP-ribose) polymerase-1 and NF-kB expression (associated with microglial activation) were associated with higher glucose concentrations.27 28 In EPT infants, hyperglycaemia >8.3 mmol/L on the first day of life was associated with white matter reduction at term-equivalent age.7 A meta-analysis concluded that neonatal hypoglycaemia was associated with visual-motor impairments, thus implying a possible effect of hyperglycaemia on motor development.29