CEBPB and Sepsis: We recently demonstrated that newborn BCG vaccination initiates an emergency granulopoiesis response (mediated by transcription factor CCAAT/enhancer-binding protein beta; CEBP-β) which was directly responsible for providing protection against polymicrobial sepsis through a BCG-augmented increase in neutrophil numbers, with no evidence for alterations in the neutrophil function (Fig. 1) [17].