VDR and immune system disorder: Studies have indicated that VDR polymorphisms are associated with Vit-D levels and exhibit a genetic predisposition for vitiligo.3, 36 Though the etiopathogenesis of vitiligo is not completely clear, Vit-D is known to mediate immune regulation and immune diseases in addition to diabetes and cardiovascular diseases among others.1, 2, 3 It is also known that vitiligo is associated with autoimmune comorbidities and therefore altered circulatory Vit-D levels may be associated with vitiligo patients.