The hub genes of EGF and OLFM4 may be involved in the occurrence and progression of AKI and QPCT, CKAP4, PRKCQ, PLAC8, PRC1, BCL9L, ATP11B, KLHL2, LDLRAP1, NDUFAF1, IFIT2, CSF1R, HGF, NRN1, GZMB, and STAT4 may be associated with septic shock. The gene discussed is NDUFAF1; the disease is acute kidney injury.