The hub genes of EGF and OLFM4 may be involved in the occurrence and progression of AKI and QPCT, CKAP4, PRKCQ, PLAC8, PRC1, BCL9L, ATP11B, KLHL2, LDLRAP1, NDUFAF1, IFIT2, CSF1R, HGF, NRN1, GZMB, and STAT4 may be associated with septic shock. This evidence concerns the gene PLAC8 and septic shock.