Examples include RIVAL 01/TBio-6517, a Vaccinia virus for tumor-directed expression of FLT3L, anti-CTLA-4, and IL-12 (NCT04301011), and ONCR-177 (NCT04348916), an HSV-1 mediating expression of IL-12, FLT3LG, CCL4, anti-PD-1, and anti-CTLA-4 to enhance induction of tumor-specific adaptive immunity. The gene discussed is CTLA4; the disease is neoplasm.