In a second brain cohort from the USC ADRC neuropathology core (Supplementary table 1), nonsignificant differences were observed in p-cPLA2/total cPLA2 in the hippocampus of the APOE4/E4 AD group compared to the APOE3/E3 NCI group (Fig. S4A), despite a significantly greater ratio of p-p38/ total p38 in the APOE4/E4 AD group (Fig. S4B). This evidence concerns the gene APOE and Alzheimer disease.