GABRA1 and in situ carcinoma: In the PFC, analysis of the change in the mRNA level of GABRA1 revealed significant effects of age [F(1, 32) = 18.563, P < 0.05], CIS exposure [F(1, 32) = 9.227, P < 0.05] and their interaction [F(1, 32) = 9.509, P < 0.05].