Univariate logistic analysis of the training cohort showed that 24 factors, including age, hypertension, DM, hypertension, CHD, CVD, cancer, White blood cells (WBC), Neutrophil (N), Hemoglobin (HB), Monocyte (Mono), whether lymphocyte (Lym) ≥ 0.8 × 109/L, Platelet (PLT), prothrombin time (PT), Fibrinogen (Fib), D-Dimer, lactate dehydrogenase (LDH) ≥ 400 U/L, aspartate Aminotransferase (AST), alanine aminotransferase (ALT), ASTpeak, ALTpeak, Albumin (ALB), Creatinine, Creatinine peak, CRP, and PCT were significantly associated with deterioration risk (Table 2). The gene discussed is F2; the disease is diabetes mellitus.